講者：HP Authorized Customer
日期：2019-12-13
觀看: 818
  • 00:00 1.
    Foods for Healthy EpigeneticsInternational Council of Nurses Nightingale Challenge
  • 07:21 2.
    Epigenetics & Precision Medicine, Precision Health & SystemsGene-Environment Interactions: Therapeutic Lifestyle InterventionsFor Population HealthNational Institutes of Health: All of Us Research https://www.joinallofus.org/en/aboutAmerican Association o
  • 11:09 3.
    NIH All of Us Research Programto build a national research cohort of n=1 million+ reflecting the diversity of the US, 10-year follow up on individual health, habits, environment, family history, by extending precision medicine to develop more effective pe
  • 12:17 4.
    a renewed vision for new generation of nursing scientists, to conduct cutting-edge research in the key emerging areas of health sciences research omics and the microbiome; health behavior, behavior change, biobehavioral science; patient-reported outcomes
  • 13:06 5.
  • 14:20 6.
    Phenotype: physical, behavioral, & biochemical characteristics of an organism, result of gene-environment interactions: height, weight, facial features, skin color, personality, oral and writing attributes, wound healing, responses to drugs, immunity, blo
  • 15:55 7.
  • 16:24 8.
    Gene
  • 17:23 9.
    Gene expressed – loosened Histone (组蛋白)Chromatin (染色质) protein binding chemistry
  • 18:06 10.
    Epigenetics-Methylation Cycle, Methyl Donors, Nutrients, Gene Expression, and Histone Modification
  • 24:18 11.
    Methylation pathways –MTHFR gene
  • 24:55 12.
    Methylation - Key Mechanism of Epigenetics
  • 27:50 13.
    From Public Health Genomics to Precision Public Health 20 year Journey, 2017 Muin J. Khoury, MD, PhD, CDC National Office of Public Health Genomicshttp://www.cdc.gov/genomics/training/file/print/10year/Khoury.pdf
  • 29:16 14.
    Conceptual Framework: Meta-Prediction Gene-Environment Interactions and Health Risks
  • 31:30 15.
    Air Pollution in the World
  • 32:22 16.
    Air Pollution & Gene Polymorphisms
  • 32:24 17.
    Air Pollution in the World
  • 33:11 18.
    Air Pollution & Gene Polymorphisms
  • 34:09 19.
    Meta Prediction - Air Pollution: GSTM1 Deletion, Lung Cancer Risk
  • 34:56 20.
    Meta-analysis: Risk of Gene PolymorphismsAlzheimer’s Disease, Vascular, Risk ratio >2
  • 36:05 21.
    Human Groups in the World – Mitochondrial Trace
  • 38:13 22.
    Human Migration – Y Chromosome Trace
  • 38:42 23.
    Conceptual Framework:Gene-Environment Interactions and Health Outcomes
  • 39:10 24.
    Meta-analysis 荟萃分析 : Homocysteine 同型半胱氨酸, MTHFR Gene Polymorphism, Disease Risks
  • 39:41 25.
    Increased Homocysteine 同型半胱氨酸 Levels Chronic Health Conditions and Cancer
  • 40:55 26.
    Compound Gene Mutations Examples
  • 41:49 27.
    Epigenetics-Methylation Cycle, Methyl Donors, Nutrients, Gene Expression, and Histone Modification
  • 42:00 28.
    Different Methylation Patterns of Ethnic Groups
  • 43:20 29.
    Different Mutations of Ethnic Groups – Folate (B9)
  • 44:53 30.
    Different Mutations of Ethnic Groups – Vit. B12
  • 45:55 31.
    Hypo-Methylation: Differential Methylated RegionsCancer, Family, Obese, Non-Obese Whole Genome
  • 46:57 32.
    Glucose transporter proteins GLUT1-5, Insulin Resistance(GLUT1/SLC2A1 promoter, GLUT3/SLC2A3 Intron hypomethylation DNAm, increase expression, Cancer/Control, families/control, obesity/control).
  • 47:10 33.
    Predictors of Cancer: Gene Environment InteractionIn Multi-ethnic Families
  • 47:18 34.
    Predictors of Cancer: Gene Metabolites InteractionMulti-ethnic Families
  • 47:47 35.
    Predictors of Cancer: Gene Diet Interaction, Families
  • 48:02 36.
    Predictors of Cancer: Gene Metabolites InteractionMulti-ethnic Families
  • 48:21 37.
    Predictors of Cancer: Gene Diet Interaction, Families
  • 48:22 38.
    PMID: 30322146, 2018
  • 48:24 39.
    Predictors of Cancer: Gene Diet Interaction, Families
  • 48:28 40.
    PMID: 30322146, 2018
  • 49:00 41.
    PMID: 30322146, 2018
  • 49:32 42.
    PMID: 30696735 2019
  • 51:03 43.
    PMID: 30322146, 2018
  • 51:29 44.
    PMID: 30322146, 2018
  • 51:42 45.
    PMID: 30784572, 2019
  • 51:56 46.
    Mammalian Target Of Rapamycin (mTOR) ComplexSignaling and Regulation by the Lysosome 溶酶体 and Aging
  • 52:19 47.
    Mammalian Target Of Rapamycin (mTOR) ComplexSignaling and Regulation by the Lysosome 溶酶体 and Aging
  • 52:50 48.
    Branched Chain Amino Acids, Insulin Resistance
  • 54:06 49.
    PMID: 30322146, 2018
  • 54:18 50.
    Maternal Vit B12 associated with obesity, M/C insulin resistance
  • 55:04 51.
    Vitamin D https://www.youtube.com/watch?v=qvNLNl7oJnM
  • 55:26 52.
    ~10% Protein Coding Human Genome need Vit. D enzyme NHANES (CDC): 1-70 yrs: 600 IU/day; 70+ yrs: 800 IU/day> 20 ng/ml blood levels CYP2R1 gene, Vit D deficiency: accelerate AgingTPH1 (Tryptophan hydroxylase 1): gutTPH2: BrainFoods:Milk: 100 IU/8oz, Egg y
  • 56:25 53.
    Healthy Eating Index per Social-Ethnic Diets
  • 56:34 54.
    Calories from Carbohydrates and Proteins per Social-Ethnic Diets
  • 57:05 55.
    Irritable bowel syndrome 过敏性肠综合征 Low FODMAP (Fermentable oligo-, di-, mono-saccharides & polyols)Meta-analysis:6 RCTs + 16 non randomized interventions:Improved with decreased symptoms, quality of life, abdominal pain
  • 57:40 56.
    PMID: 30322146, 2018
  • 57:43 57.
    Slide 51
  • 57:45 58.
    PMID: 30322146, 2018
  • 57:48 59.
    Slide 51
  • 57:53 60.
    Slide 52
  • 57:54 61.
    Slide 53
  • 57:55 62.
    Slide 54
  • 57:55 63.
    Slide 55
  • 57:56 64.
    Slide 56
  • 57:57 65.
    Slide 57
  • 57:57 66.
    Lectins 凝集素 PMID: 10205084 1999, 28087670, 2017, 30755589 2019plant lectins represent “danger molecules” capable of activating the NLRP3 inflammasome, promoting inflammation and mitochondrial damage. Potency to develop anti-inflammation and Tumor Control
  • 59:03 67.
    Lectin 凝集素 Sensitivity
  • 59:38 68.
    Higher Lectin:All legumes (e.g. dried beans, lentils, peanuts- peanut butter and peanut oil, soybeans chickpeas)Nightshade 茄属植物 foods (e.g. eggplant, potatoes, tomatoes, bell peppers, gogi berries)Grains (wheat and wheat germ cakes, crackers, and bread) D
  • 1:01:37 69.
    Take care of your 50-70 billion new cells and DNAs/day
  • 1:01:48 70.
    PMID: 30322146, 2018
  • 1:02:53 71.
    Comparison on Healthy Eating Index
  • 索引
  • 筆記
  • 討論
  • 全螢幕
Food for healthy Epigenetics 2019 dec10 session 2
長度: 1:06:38, 瀏覽: 819, 最近修訂: 2019-12-13
    上一篇 下一篇
    • 00:00 1.
      Foods for Healthy EpigeneticsInternational Council of Nurses Nightingale Challenge
    • 07:21 2.
      Epigenetics & Precision Medicine, Precision Health & SystemsGene-Environment Interactions: Therapeutic Lifestyle InterventionsFor Population HealthNational Institutes of Health: All of Us Research https://www.joinallofus.org/en/aboutAmerican Association o
    • 11:09 3.
      NIH All of Us Research Programto build a national research cohort of n=1 million+ reflecting the diversity of the US, 10-year follow up on individual health, habits, environment, family history, by extending precision medicine to develop more effective pe
    • 12:17 4.
      a renewed vision for new generation of nursing scientists, to conduct cutting-edge research in the key emerging areas of health sciences research omics and the microbiome; health behavior, behavior change, biobehavioral science; patient-reported outcomes
    • 13:06 5.
    • 14:20 6.
      Phenotype: physical, behavioral, & biochemical characteristics of an organism, result of gene-environment interactions: height, weight, facial features, skin color, personality, oral and writing attributes, wound healing, responses to drugs, immunity, blo
    • 15:55 7.
    • 16:24 8.
      Gene
    • 17:23 9.
      Gene expressed – loosened Histone (组蛋白)Chromatin (染色质) protein binding chemistry
    • 18:06 10.
      Epigenetics-Methylation Cycle, Methyl Donors, Nutrients, Gene Expression, and Histone Modification
    • 24:18 11.
      Methylation pathways –MTHFR gene
    • 24:55 12.
      Methylation - Key Mechanism of Epigenetics
    • 27:50 13.
      From Public Health Genomics to Precision Public Health 20 year Journey, 2017 Muin J. Khoury, MD, PhD, CDC National Office of Public Health Genomicshttp://www.cdc.gov/genomics/training/file/print/10year/Khoury.pdf
    • 29:16 14.
      Conceptual Framework: Meta-Prediction Gene-Environment Interactions and Health Risks
    • 31:30 15.
      Air Pollution in the World
    • 32:22 16.
      Air Pollution & Gene Polymorphisms
    • 32:24 17.
      Air Pollution in the World
    • 33:11 18.
      Air Pollution & Gene Polymorphisms
    • 34:09 19.
      Meta Prediction - Air Pollution: GSTM1 Deletion, Lung Cancer Risk
    • 34:56 20.
      Meta-analysis: Risk of Gene PolymorphismsAlzheimer’s Disease, Vascular, Risk ratio >2
    • 36:05 21.
      Human Groups in the World – Mitochondrial Trace
    • 38:13 22.
      Human Migration – Y Chromosome Trace
    • 38:42 23.
      Conceptual Framework:Gene-Environment Interactions and Health Outcomes
    • 39:10 24.
      Meta-analysis 荟萃分析 : Homocysteine 同型半胱氨酸, MTHFR Gene Polymorphism, Disease Risks
    • 39:41 25.
      Increased Homocysteine 同型半胱氨酸 Levels Chronic Health Conditions and Cancer
    • 40:55 26.
      Compound Gene Mutations Examples
    • 41:49 27.
      Epigenetics-Methylation Cycle, Methyl Donors, Nutrients, Gene Expression, and Histone Modification
    • 42:00 28.
      Different Methylation Patterns of Ethnic Groups
    • 43:20 29.
      Different Mutations of Ethnic Groups – Folate (B9)
    • 44:53 30.
      Different Mutations of Ethnic Groups – Vit. B12
    • 45:55 31.
      Hypo-Methylation: Differential Methylated RegionsCancer, Family, Obese, Non-Obese Whole Genome
    • 46:57 32.
      Glucose transporter proteins GLUT1-5, Insulin Resistance(GLUT1/SLC2A1 promoter, GLUT3/SLC2A3 Intron hypomethylation DNAm, increase expression, Cancer/Control, families/control, obesity/control).
    • 47:10 33.
      Predictors of Cancer: Gene Environment InteractionIn Multi-ethnic Families
    • 47:18 34.
      Predictors of Cancer: Gene Metabolites InteractionMulti-ethnic Families
    • 47:47 35.
      Predictors of Cancer: Gene Diet Interaction, Families
    • 48:02 36.
      Predictors of Cancer: Gene Metabolites InteractionMulti-ethnic Families
    • 48:21 37.
      Predictors of Cancer: Gene Diet Interaction, Families
    • 48:22 38.
      PMID: 30322146, 2018
    • 48:24 39.
      Predictors of Cancer: Gene Diet Interaction, Families
    • 48:28 40.
      PMID: 30322146, 2018
    • 49:00 41.
      PMID: 30322146, 2018
    • 49:32 42.
      PMID: 30696735 2019
    • 51:03 43.
      PMID: 30322146, 2018
    • 51:29 44.
      PMID: 30322146, 2018
    • 51:42 45.
      PMID: 30784572, 2019
    • 51:56 46.
      Mammalian Target Of Rapamycin (mTOR) ComplexSignaling and Regulation by the Lysosome 溶酶体 and Aging
    • 52:19 47.
      Mammalian Target Of Rapamycin (mTOR) ComplexSignaling and Regulation by the Lysosome 溶酶体 and Aging
    • 52:50 48.
      Branched Chain Amino Acids, Insulin Resistance
    • 54:06 49.
      PMID: 30322146, 2018
    • 54:18 50.
      Maternal Vit B12 associated with obesity, M/C insulin resistance
    • 55:04 51.
      Vitamin D https://www.youtube.com/watch?v=qvNLNl7oJnM
    • 55:26 52.
      ~10% Protein Coding Human Genome need Vit. D enzyme NHANES (CDC): 1-70 yrs: 600 IU/day; 70+ yrs: 800 IU/day> 20 ng/ml blood levels CYP2R1 gene, Vit D deficiency: accelerate AgingTPH1 (Tryptophan hydroxylase 1): gutTPH2: BrainFoods:Milk: 100 IU/8oz, Egg y
    • 56:25 53.
      Healthy Eating Index per Social-Ethnic Diets
    • 56:34 54.
      Calories from Carbohydrates and Proteins per Social-Ethnic Diets
    • 57:05 55.
      Irritable bowel syndrome 过敏性肠综合征 Low FODMAP (Fermentable oligo-, di-, mono-saccharides & polyols)Meta-analysis:6 RCTs + 16 non randomized interventions:Improved with decreased symptoms, quality of life, abdominal pain
    • 57:40 56.
      PMID: 30322146, 2018
    • 57:43 57.
      Slide 51
    • 57:45 58.
      PMID: 30322146, 2018
    • 57:48 59.
      Slide 51
    • 57:53 60.
      Slide 52
    • 57:54 61.
      Slide 53
    • 57:55 62.
      Slide 54
    • 57:55 63.
      Slide 55
    • 57:56 64.
      Slide 56
    • 57:57 65.
      Slide 57
    • 57:57 66.
      Lectins 凝集素 PMID: 10205084 1999, 28087670, 2017, 30755589 2019plant lectins represent “danger molecules” capable of activating the NLRP3 inflammasome, promoting inflammation and mitochondrial damage. Potency to develop anti-inflammation and Tumor Control
    • 59:03 67.
      Lectin 凝集素 Sensitivity
    • 59:38 68.
      Higher Lectin:All legumes (e.g. dried beans, lentils, peanuts- peanut butter and peanut oil, soybeans chickpeas)Nightshade 茄属植物 foods (e.g. eggplant, potatoes, tomatoes, bell peppers, gogi berries)Grains (wheat and wheat germ cakes, crackers, and bread) D
    • 1:01:37 69.
      Take care of your 50-70 billion new cells and DNAs/day
    • 1:01:48 70.
      PMID: 30322146, 2018
    • 1:02:53 71.
      Comparison on Healthy Eating Index
    位置
    1. 知識庫
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    資料夾名稱
    學術演講
    發表人
    江堤莊
    單位
    台大醫學院資訊組
    建立
    2019-12-13 15:42:15
    最近修訂
    2019-12-13 17:09:02
    長度
    1:06:38